Transcripts
DR. MAUSETH:
You have a
whole pancreas in this portion and no use
mentioning 20 percent or so of patient have
pancreatitis. And pancreatitis, the definition
of that, is inflammation of the pancreas. And
if you look at the pancreas, it has these
little black dots in it here, and each one of
those black dots represents an islet cell.
So this is a blown up picture
of an islet cell and you can see that the blue
staining in here are the cells that make
insulin. And these cells in here are called the
asterion cells and they make actually digestive
juices and help you digest fats and proteins.
The islet cell, however, in
here, has the ability to secrete insulin. And
insulin secretion is the major cause of problems
with diabetes.
Now, there are two major causes
of diabetes that we know of, one is type one
and other is type two diabetes. In type one
diabetes, these islet cells are inflamed and
damaged and you lose them and they essentially
become fibrotic.
In type two diabetes, the islet
cells are huge and what the problem is there is
that the insulin secretion is not adequate. And
we will discuss that a little bit later.
If you blow this up even
farther you can see that there are vascular structures
around here that surround the islet
cells in this portion. And when we start
looking at this with Hemolytic Uremic Syndrome,
it's not really known what causes the injury,
here, as I am sure that you've gotten that from
the text and comments so far, but we're not
exactly sure what causes that injury and to what
extent it causes it in different patients.
