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DR. MAUSETH:
     Now, when you look at sugar metabolism you have these big cells here and each of the cells has a place on the surface of the cell called a receptor. Insulin molecules float around in the blood stream and attach to the receptor, and when they're attached to the receptor, they allow sugars to go into the cells and to nourish the cells.
      When sugar doesn't get into the cells, the cells essentially go into a state of starvation and that is where you get weight loss and muscle breakdown and lethargy and those kinds of symptoms.
      And in general, when the sugar stays in the blood stream, then it gets into the kidneys. And when it gets into the kidneys in the normal kidney, then it will cause the person to start urinating more than normal. Now, keep this in mind because we're going to come back to the difference, here.
      There are a lot of things that can affect how the insulin attaches to the islet's receptor, here. And there are many things that can affect the way the receptor works, and one of those is stress.
      Stress will make these receptors not as active as normal. Stress also can cause other hormones to create more sugar to come into the body. Obesity will make the receptors not work as well. And puberty will also make those not work as well.
      And so when we come -- later on in the talk, we will be discussing when you might look for onsets of diabetes. There will be a difference between type one and type two diabetes.




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