Transcripts
DR. LINGWOOD:
This shows overlays of
primary cancer tissue with the toxin. And what
you see here is that, like in the pediatric
kidney, blood vessels which are in a tumor, also
stain with verotoxin.
And particularly here is shown a
highly stained differentiated but drug resistant
tumor. Whereas this one, which is a similarly
well differentiated drug sensitive ovarian tumor,
this shows no VT staining. Prognosis is good
here and bad here. But here you see there's
increased binding of verotoxin. I don't want to
go through this but what we've done is taken the
MDR gene responsible for drug resistance, (kidney
is the major site of expression in normal
tissue) and transfected it into cells.
