Transcripts
DR. LINGWOOD:
And you see that sensitivity to
verotoxin goes from the green line to this, it
increases by a million times, and what happens
is that when you transfect the MDR drug pump into
cells, whereas the parent cell makes no Gb3, the
transfected cell makes lots of Gb3 and
if you inhibit it with cyclosporin a major
inhibitor of MDR (which can actually be an
inducer of HUS), you see a reduction in Gb3.
