Transcripts
DR. LINGWOOD:
There are several things that
can compromise the epithelial barrier and one of
them is the mechanism by which the intact E.
coli organism binds to the gastrointestinal
mucosa. And here is shown enteropathic E. coli
relative to enterohemorrhagic E. coli that make
verotoxin. And they undergo this and so does
hemorrhagic E. coli, this very complex procedure
of attachment to an epithelial cell.
They have these long what's
called bundle forming villi which touch down on
the cell, and then this becomes closer. There's
some reorganization of actin filaments underneath
the bacterial cells that are stuck on the cell.
And then they form this huge pedestal on the
cell surface, and that's shown here.
So you see most of the villi
are removed from the cell and they form this
pedestal with bacterium stuck on the top.
