Transcripts
DR. LINGWOOD:
And this is perhaps more a
conventional section. These are the villi, and
you can see staining here in the crypts. Well,
if you want to come up closer, you can see
staining at the base of these villi. And what
I've learned from my collaborators in Edinburgh
in Scotland just this last week is that they've
taken some bovine colon and treated it with
verotoxin and then examined this area of the
epithelium and found that it caused, within 12
hours, a marked increase of these primitive
cells.
So what happens is the cells
are primitive, here, they differentiate and move
along the villus and are shed out here. So the
cells early in the differentiation of the
epithelium of the colon express the receptor and
are stimulated to grow by verotoxin.
And what that means in terms of
pathology, in terms of colonization, we have yet
to establish, but it establishes a new effect
for verotoxin and a new perspective on the
reservoir, the bovine host.
