Transcripts
DR. LINGWOOD:
I should point out, now I see
it on this slide, mostly the human outbreaks are
involved with STX2 or verotoxin 2. And I should
point out, as I will do, that the lipid
structure differentially affects the binding of
VT2 as opposed to VT1.
SPEAKER:
Can you speak to the
preexisting factors; what does that mean?
DR. LINGWOOD:
Well, why don't
you actually ask Dr. Tarr, he's here, because as
I say, I borrowed this slide from him for this
part. These are possible risk factors that he
has identified, age, race. It's been believed
that HUS is less common in blacks, but we have
evidence that the receptor distribution is the
same in -- in all -- in essentially all races
in terms of kidney -- kidney expression.
P1 is a form, if you like, of
Gb3 which is, as I said before, is also called
pK, which is a blood group antigen, and P1 is one of the
blood group antigens in this blood
group series.
Everybody knows about age, and I
will be addressing that, too, because there is a
difference in Gb3 expression with age and,
actually, this slide shows it.
