Transcripts
DR. ROCK:
Now, the typical disease lesion
is a hyaline microthrombus; in other words, an
amorphous staining protein deposit in the blood
vessels, particularly in the small blood vessels,
with platelet aggregates and fiber. As such,
these lesions and clots are unlike those that we
see in disseminated intravascular coagulation.
They are not enriched in
fibrinogen, one of the clotting proteins, but
rather are highly enriched in von Willebrand
factor, the protein which is deficient in
patients with von Willebrand's disease. The
other thing we didn't see is endothelial cell
proliferation or certainly a reaction.
