Transcripts
DR. ROCK:
Now, one of the first things I
would say to you is that in the adult setting
it is extremely difficult to separate out in a
specific fashion the disorders of Thrombotic
Thrombocytopenic Purpura and Hemolytic Uremic
Syndrome.
DR. ROCK:
Now, TTP is what we call a
micro angiopathy and was first described in 1924,
by Moschowitz, who had a 16-year-old patient who
went into coma and then died from the deposition
wide-spread in the body of platelet microthrombi.
And while the disease has been
around for a very long period of time, it really
wasn't until 1998, when two different groups
those led by Dr. Tsai, in New York, and Furlan
in Switzerland demonstrated the presence in the
patient's plasmids of an antibody directed
against an enzyme and associated it with the
pathophysiology of the disease.
