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MS. ORRBINE:
      In 1991 a group which I will describe for you in a few minutes a group referring to the Canadian Pediatric Kidney Disease Research Center studied 22 survivors of HUS whose neurological function was grossly normal at discharge from hospital.
      Pointing out, though, that six of those 22 children did experience seizures or coma again during the acute episode but were normal neurologically at the time of discharge.
      We identified a nonspecific trend in these 22 children toward deficits in some aspects of verbal intelligence, language skills and behavioral control. Statistical comparisons, as you can appreciate on a sample size of 22 children just wasn't -- we weren't able to establish any sort of statistical significance. The sample size, of course, was too small.




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