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MS. ORRBINE:
Just as a very quick background,
and I'm kind of glad that this slide was
included, I included this slide because I think
one of the things that perhaps hasn't been
emphasized today or at least stated is that
Hemolytic Uremic Syndrome is, in fact, the
leading cause of acute renal failure in a child.
Typically HUS follows a
gastrointestinal illness caused by strains of E.
coli that elaborate verotoxin or Shiga toxins or
STS. We all know exactly what we're referring
to.
Again, as mentioned by Dr.
Brandt and Dr. Tarr it's important to mention
that the studies we're going to talk about this
afternoon, in fact, are studies on children who
have diarrhea, E. coli, Hemolytic Uremic
Syndrome.
HUS has an annual incidence of
1.44 to 1.74 hundred thousand children less than
15 years of age in North America.
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