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DR. MAUSETH:
     We did oral glucose tolerance tests on a lot of the patients, oral glucose tolerance in Jeff Brandt's follow-up study. Many of these are somewhat difficult to do. They're not tremendously hard, but I think that if you found an abnormal glucose tolerance test you would be somewhat concerned. But the question would be would you treat them with anything.
      So as far as a parent wondering if they're going to change something with their child's medical care I think the bottom one here is probably easiest. Parents would look at this and say, okay, when should I be doing something about the possibility of glucose intolerance. And that's usually when you're having a blood sugar over about 175.
      And sugar starts showing up in the urine at about 175. And that can be done by a simple test looking at your -- collecting the sample of urine or having a child urinate on a dipstick, which can be bought over the counter at stores. And I would do this in periods of stress, periods of illness, or anytime someone felt like they were having symptoms.
      But, again, even though you haven't had diabetes in -- in the period of the acute illness, I wouldn't discount it later on as being a possibility.
      Diabetes is not a frequent thing with HUS, but it can be significant. Again, I would warn you that you really want to be aware that as kids grow, kids gain weight and that kind of thing, they can change. And that's one of the problems with the studies that have been done is we really don't know where these kids are going to end up when they're 30, 40, 50 years old.




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