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DR. MAUSETH:
And in type one diabetes we
followed patients. There are now a number of
national studies looking at close relatives
trying to prevent type one diabetes. And what
we see is that you can have normal pancreas
function out here, normal release of insulin, and
it's not until you lose about 30 percent of your
islet cell function that you actually get an
abnormal laboratory test.
Now, these patients are totally
asymptomatic at this stage and most of them are
asymptomatic when they get to the oral glucose
tolerance phase, but it's not until they've lost
90 percent or so of their islet cell function
that they become symptomatic.
Now, there are factors that can
make a patient symptomatic earlier, such as
stress or such as growing or such as obesity
that can make more stress or more need for
insulin production.
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