Transcripts
DR. BRANDT:
So what happens to the kidney as HUS resolves? Well, the areas of cell hypoxia mostly return to normal and areas of thrombotic microangiopathy mostly return to normal. The body has a process for getting rid of the clots in the blood vessels and cleaning the blood vessels back out.
But areas of necrosis, areas where cells have in large numbers died, form scar tissues. So those areas are gone for good.
Now, E. coli-associated HUS is a self-limited process. This is very different from TTP or some of the other rare forms of HUS. This HUS goes away. Once the E. coli and its toxin is gone, the process stops. Any damage that's left is predominantly due to necrosis and scar tissue formation.
Long term outcome after HUS predominantly has to do with how much permanent scar formation you have and which organs that scar formation is in.
