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DR. TARR:
      The most common form of gastrointestinal problems that we're confronted with involving E. coli infections in general, and HUS in particular, and I'm not certain that there's really that much of a difference between the two is something that resembles irritable bowel syndrome.
      The child comes in complaining of diffuse abdominal pain or holding the belly button. There's a rule in pediatrics that the further you are from your belly button when you point to where it hurts the more likely you are to come up with a diagnosis. If a child just doubles over holding the belly button or holding the whole abdomen, this can be a very frustrating problem to evaluate, whether or not they have E. coli infection.
      It is believed, and I will go into this in a little while, that this is probably secondary to some abnormal visceral sensation. And I will show you a graph that suggests that this might underlie this.
      Now, whether or not IBS is triggered by the infection is hard to know. 15 percent of the population supposedly has irritable bowel syndrome, if one asks, if one distributes questionnaires to the general population. So it's a very common background problem in the general population.




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