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DR. TARR:
      Acutely, we see vomiting; small bowel symptoms consisting of non-bloody diarrhea; and bloody diarrhea which suggests a colonic abnormality in the gastrointestinal tract.
      The right lower quadrant, in the region of the appendix, is often quite inflamed in such children. And my colleagues in radiology who perform abdominal ultrasounds frequently see parts of the small bowel surrounding the appendix being quite swollen.
      And it's also not uncommon for a surgeon to be consulted in the work-up of such a child and sometimes it's appropriate to perform a very quick exploratory abdominal operation.
      One can see appendicitis in the setting of an acute E. coli infection and it would be tragic to overlook such a treatable disease. It is much better to have a very brief operation to make certain that there's nothing in the abdomen that's surgically remediable, even if you have a pretty good idea that you're dealing with E. coli infection.
      In the colon the symptoms consist chiefly of the bloody diarrhea, which occurs 80 to 90 percent of the time in children who have acute E. coli 0157:H7 infection.
      Rectal prolapse can also be a sign of E. coli 0157:H7 infections. Also one can see intussusception where the colon telescopes upon itself, a complication that can frequently be reduced with an air enema with the radiologist's participation. On rare occasions it will require an operation to reduce, in which case this too would be another indication for a surgical procedure.
      In any case, it's very valuable to have an experienced pediatric surgeon assessing such a child because the pain is intense, as you're quite aware and a well-considered thought process is often necessary to decide what should be done.




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