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DR. ROCK:
      I would like to say a few words now about the relapses in our patients. We've been following some of our patients through up to 10 years, of course those who entered the studies near the end we only have a few years' data on, but basically overall at this point in time we are seeing a 35 percent relapse over this 10-year period.
      The interesting thing from my perspective on this is that, as I told you before, there's nothing particularly predictive, according to the laboratory markers, but there's also no pattern for the relapses. You can see that some patients relapse early in the course of disease; others very late.
      This patient was perfectly fine for years and years and then relapsed. But we're at the point now where the patients themselves are all being taught that such relapses are possible. And I have had patients represent to me simply by phoning up and saying I've got a few small blue spots on my arm, do you think I should come in, and they came in and they were right. So we were able to get them very early in the disease and there's no question at all that this therapy, which is removing material and replacing material, is absolutely best done if done early in the course of the disease.




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