Transcripts
DR. LINGWOOD:
So what we see is that the long
chain Gb3 species tend to get stuck in the
Golgi, whereas the shorter chain Gb3 species
targets the toxin further down this
internalization route transport called a
retrograde transport pathway into the Golgi into
the endoplasmic reticulum and here. So that's
two pathways. There are more.
I already told you that not all
cells are killed by verotoxin. One such cell
type are monocytes. They are induced to produce
cytokines following verotoxin exposure.
Monocytes are induced to produce
cytokines by verotoxin as opposed to being
killed.
