Transcripts
DR. LINGWOOD:
Part of the background
for this arose from looking at
three different astrocytoma cell lines, here,
which have the same amount of Gb3, the receptor,
but show different sensitivity to verotoxin.
But there are other examples.
The yellow cell is killed by verotoxin at low
concentrations, but the bluey-green cell has the
same amount of Gb3 but is fairly resistant.
And if you treat the green cell
line with sodium butyrate -- butyrate is a short
chain fatty acid C34 -- if you treat it with
that compound that increases VT sensitivity of
this green cell to become the red cell. And
the red cell you can see, is just as sensitive,
in fact, more sensitive than the yellow cell.
So we can change the sensitivity
of the cells. Firstly, the cells have
differential sensitivity despite equal Gb3
concentration and we can change one to the other
by using sodium butyrate. So remember that.
