Transcripts
DR. LINGWOOD:
Now, this is the receptor, Gb3
- Globotriaosyl ceramide, it is a glycolipid.
That means it's a sugar and a lipid conjugated
together. So this is the lipid structure which
fits into the cell membrane of the sensitive
cell. And this is the sugar. This is a space
filling module, which has three sugars and it's
these two terminals to which the toxin binds.
And which is available on the cell surface for
the toxin to bind to.
It's the dynamics of this
interaction between the "B" subunits of the toxin
and this glycolipid receptor, Gb3, also called
pK, also called CD77 and human "B" cell
differentiation marker, that determines the
eventual outcome of cell contact with these
toxins.
